Currently, intestinal permeability is evaluated by measuring proteins in the blood. However, with TestUrGut it is possible to observe if there is a decrease in the butyrate-producing bacteria of the intestinal mucosa, a factor that can increase the intestinal permeability favoring an inflammatory state.
Intestinal permeability is usually a consequence of alterations of the tight junctions between cells of the intestinal wall, which decrease leads to increased transport of components and or undesired bacteria into the bloodstream that can trigger chronic inflammation or immunity disorders. Several studies have analyzed the effect of butyrate on intestinal permeability, concluding that it induces the expression of junction proteins, hence keeping permeability (Hamer 2007, Peng 2009, Kelly 2005).
Therefore, dysbiosis or significant alterations in the abundance of muco-nutritive bacteria indicate incremented intestinal permeability.